Victorian Anthony Dell'Orso sits on the precipice of Australian basketball history and isn't shying away from achieving what he calls the most difficult title in sport.

Dell'Orso (University of Arizona) and fellow Australian Jacob Furphy (University of Connecticut) will represent their colleges in the March Madness Final Four, with passage to the final of the United States' top college basketball tournament up for grabs.

They are aiming to join an exclusive club of Australian men to have been members of championship-winning teams, with Justin Brown (1999), Kody Stattmann (2019), and Alex Condon (2025) the only victors.

Condon is also the sole Australian man to play in and win the final.

If Dell'Orso and Furphy make the big dance on Monday (Tuesday AEST), it will also be the first time two Australians have faced off in a championship game.

However, Dell'Orso's Arizona must scale the steep challenge of beating the No.1-ranked Michigan in front of some 70,000 people in Indianapolis when the semi-finals are played on Saturday (Sunday AEST).

"It's one of the most difficult things to achieve in sports. You have one game elimination every round, and anything can happen," he told AAP.

"To already have made history, that's pretty cool. We have to basically go as hard as we've ever gone.

"There's no reason to back off now, just because we've made something that hasn't been done in 25 years."

Arizona made the Final Four of the knock-out tournament for the first time since 2001, and all eyes will be on their fairytale story after more than 36 million people submitted "March Madness brackets" predictors ahead of the competition.

Dell'Orso knows this may be one of the last times he plays for his college, declaring he will put his name up for the NBA after the season.

"The NBA is my goal. Coming here was a big step in the right direction to try and make that happen," the 22-year-old said.

"If you have a good moment, there's definitely room to boost your profile."

Furphy said it would be "insane" if two Australians could play in the final, but his UConn team will have to overcome No.3 Illinois to do so.

The Boomer has spent much of his freshman season on the bench for the six-time national championship winners, but is still relishing the occasion.

"It's crazy coming from a little town, Smithton, in Tasmania. There are 2500 people, so you're never really expecting to move away from home and make it here," the 19-year-old told AAP.

"There are a lot of players, especially in America, who dream to be here, and I get to play on that high level every single day."