Two 16-year-old boys have been killed and two others seriously injured after a car smashed into trees in Perth’s north-east.

The teenagers were travelling in a grey BMW 3 Series sedan along Railway Parade in Bullsbrook when the car veered off the road and slammed into several trees about 10.20pm on Saturday.

The 16-year-old driver and a 16-year-old male passenger died at the scene.

Two other passengers, both aged 17, were rushed to Royal Perth Hospital with serious injuries.

Major crash investigators are examining the scene and have appealed for witnesses to come forward.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or make a report online here.

Dashcam, CCTV or mobile phone footage of the crash can be uploaded directly to investigators here.