Six passengers from the hantavirus-stricken MV Hondius are finally winging their way to Perth, where they are set to arrive Friday and begin a lengthy stretch in quarantine.

The flight from Eindhoven Airport in The Netherlands departed Thursday afternoon and made a refuelling stop at Al Minhad Airbase in the United Arab Emirates. It’s currently due to touch down at RAAF Base Pearce about 11.30am.

All six cruise passengers tested negative to hantavirus before the flight, authorities said.

The group will be transported directly to a quarantine facility in Bullsbrook about 7km away for an initial three-week quarantine period, where they will be regularly tested.

“They were all tested just before going onto the plane, and they all tested negative to the hantavirus and are in good shape, not showing any symptoms,” Health Minister Mark Butler reiterated this morning on ABC news.

“They’ll be tested immediately they land in Perth and have been transported to the quarantine facility there.

“There are expert staff that we’ve deployed from Darwin’s Critical Care and Trauma Response Centre who are there ready to take them, and they’ll be there for at least three weeks.”

Their plane, which departed about 4.30pm Thursday, is a Gulfstream G550 business jet capable of commercial airliner speeds.

As well as the cruise ship passengers - four Australians, a permanent resident from the UK and a New Zealander - the flight to Perth also contains medical personnel.

Officials say there are strict protocols in place to protect the passengers, those involved in their return and processing, and the broader Australian community.

“At the moment, they’ve tested negative, they’re symptom free, and they’re going to be put into the strongest quarantine arrangements you’ll find anywhere in the world,” Mr Butler said on Sky News this morning.

“Most countries are letting their repatriated passengers go back home after two or three days.

“We’re going to have at least a minimum quarantine period of three weeks, staffed by experts that have been deployed from Darwin there, because I’m determined to make sure there is zero risk of this virus getting out into our community.”

The group had been the last passengers to disembark the cruise ship in the Canary Islands on Monday.

They were flown to The Netherlands where they spent two days in hotel quarantine as the Australian Government worked to secure a charter plane and a flight crew who would be willing to quarantine in Perth.

The passengers and crew will isolate at the facility for three weeks and undergo continuous testing before an assessment is made about plans for the remainder of the 42-day incubation period.